Linking Calsequestrin to Lumenal Control of SR Ca 2+ Release
نویسندگان
چکیده
منابع مشابه
Linking Calsequestrin to Lumenal Control of SR Ca Release
The heart, beating constantly over the course of the human lifetime, operates continuously through the process of excitation-contraction coupling. Initiated by a depolarizing influx of Na, a small Ca flux across the sarcolemma causes a large release of Ca from the sarcoplasmic reticulum (SR). Release of this Ca takes place via the ryanodine receptor (RyR), a Ca channel within the SR membrane wh...
متن کاملLinking calsequestrin to lumenal control of SR Ca2+ release.
The heart, beating constantly over the course of the human lifetime, operates continuously through the process of excitation-contraction coupling. Initiated by a depolarizing influx of Na, a small Ca flux across the sarcolemma causes a large release of Ca from the sarcoplasmic reticulum (SR). Release of this Ca takes place via the ryanodine receptor (RyR), a Ca channel within the SR membrane wh...
متن کاملA calcium-induced calcium release mechanism mediated by calsequestrin.
Calcium (Ca(2+))-induced Ca(2+) release (CICR) is widely accepted as the principal mechanism linking electrical excitation and mechanical contraction in cardiac cells. The CICR mechanism has been understood mainly based on binding of cytosolic Ca(2+) with ryanodine receptors (RyRs) and inducing Ca(2+) release from the sarcoplasmic reticulum (SR). However, recent experiments suggest that SR lume...
متن کاملRegulation of ryanodine receptor opening by lumenal Ca(2+) underlies quantal Ca(2+) release in PC12 cells.
Graded or "quantal" Ca(2+) release from intracellular stores has been observed in various cell types following activation of either ryanodine receptors (RyR) or inositol 1,4,5-trisphosphate receptors (InsP(3)R). The mechanism causing the release of Ca(2+) stores in direct proportion to the strength of stimulation is unresolved. We investigated the properties of quantal Ca(2+) release evoked by ...
متن کاملMeasurement of RyR permeability reveals a role of calsequestrin in termination of SR Ca release in skeletal muscle
The intracellular signal for contraction of skeletal muscle is the rapid increase in free cytosolic [Ca]. This increase requires coordinated opening of a substantial fraction of intracellular Ca release channels of the SR, which allows for a large flux of Ca from stores to cytosol. This flux must terminate rapidly as well to allow for the fast decay of [Ca] required for mechanical relaxation. T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2007
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.107.160952